Associate Professor Leonard Mueller of the Department of Chemistry at the University of California, Riverside (UCR)

Leonard Mueller
Associate Professor of Chemistry and Vicechair of the Department
with research in
Physical Chemistry

B.S., 1988, University of Rochester
C.P.G.S., 1989, University of Cambridge
Ph.D., 1997, California Institute of Technology
ACS Postdoctoral Fellow, 1996-98, Massachusetts Institute of Technology

Office:	Chemical Sciences 1 124
Office Hours:
Lab:	Chemical Sciences 1 102
Phone:	951-827-3565
email:	leonard.mueller[at]ucr.edu

Mueller Group Site

My group at UC Riverside has developed a diverse physical chemistry research program unified through applications of nuclear magnetic resonance (NMR). There are now three distinct research directions in my group encompassing the following areas: (1) Structure and Dynamics with Solid-State NMR: emphasizing the development of novel experimental and theoretical methods; (2) Dynamic NMR: a quantum-statistical treatment of chemical exchange and new applications to kinetic and thermodynamic studies of small molecules in solution and gas phases; and (3) New Physics in NMR: quantum computing in the solid state with single crystal NMR.

Selected Publications

Rienstra, C. M.; Hatcher, M. E.; Mueller, L. J.; Sun, B.; Feski, S. W.; Griffin, R. G. "Efficent Multispin Homonuclear Double-Quantum Recoupling Magic-Angle Spinning NMR: 13C-13C Correlation Spectroscopy of U-13C-Erythromycin A," J. Am. Chem. Soc. 1998, 120, 10602-10612.

Mueller, L. J.; Weitekamp, D. P. "Quantum-Statistical Corrections to Dynamic Nuclear Magnetic Resonance," Science 1999, 283, 61-65.

Reed, C. A.; Kim, K-C.; Bolskar, R. D.; Mueller, L. J. "Taming Superacids: Stabilization of Fullerene Cations HC60+ and C60.+," Science 2000, 289,101-104.

Okamura, W. H., Zhu, G-D.; Hill, D. K.; Thomas, R. J.; Ringe, K.; Borchardt, D. B.; Norman, A. W.; Mueller, L. J. "Synthesis and NMR Studies of 13C Labeled Vitamin D Metabolites," J. Org. Chem. 2002,67(5), 1637-1650.

Mueller, L. J.; Elliott, D. W.; Kim, K-C.; Reed, C. A.; Boyd, P. D. W. "Establishing Through-Bond Connectivity in Solids with NMR: Structure and Dynamics in HC60+," J. Am. Chem. Soc. 2002, 124, 9360-9361.

Kim, K-C.; Reed, C. A.; Elliott, D. W.; Mueller, L. J.; Tham, F.; Lin, L.; Lambert, J. B. "Crystallographic Evidence for a Free Silylium Ion," Science 2002, 297, 825-827.

Rienstra, C. M.; Hohwy, M.; Mueller, L. J.; Jaroneic, C. P.; Reif, B.; Griffin, R. G. "Determination of Multiple Torsion-Angle Constraints in U-15N-13C-Labeled Peptides: 3D-1H-15N-13C-1H Dipolar Chemical Shift NMR Spectroscopy in Rotating Solids," J. Am. Chem. Soc. 2002, 124(40), 11908-11922.

Reed, C. A.; Kim, K-C.; Stoyanov, E. S.; Stasko, D.; Tham, F. S.; Mueller, L. J.; Boyd, P. D. W. "Isolating Benzenium Ion Salts," J. Am. Chem. Soc. 2003, 125(7), 1796-1804.

Mueller, L. J.; Elliott, D. W. "Correlated Tensor Interactions and Rotational-Echo Double-Resonance of Spin Clusters," J. Chem. Phys. 2003, 118(19), 8873-8881.

Leskowitz, G. M.; Olsen, R. A.; Ghaderi, N.; Mueller, L. J. "Three-Qubit NMR Quantum Information Processing with a Single-Crystal Solid," J. Chem. Phys. 2003, 119(3), 1643-1649.

Olsen, R. A.; Liu, L.; Ghaderi, N.; Johns, A.; Hatcher, M. E.; Mueller, L. J. "The Amide Rotational Barriers in Picolinamide and Nicotinamide: NMR and Ab Initio Studies," J. Am. Chem. Soc. 2003, 125(33), 10125-10132.

Olsen, R. A.; Struppe, J.; Elliott, D. W.; Thomas, R. J.; Mueller, L. J. "Through-Bond 13C-13C Correlation at the Natural Abundance Level: Refining Dynamic Regions in the Crystal Structure of Vitamin-D3 with Solid-State NMR," J. Am. Chem. Soc. 2003, 125(39) 11784-11785.

Mueller, L. J.; Elliott, D. W.; Leskowitz, G. M.; Struppe, J.; Olsen, R. A.; Kim, K-C.; Reed, C. A. "Uniform-Sign Cross-Peak Double-Quantum-Filtered Correlation Spectroscopy," J. Magn. Reson. 2004, 168(2), 327-335.

Leskowitz, G. M.; Mueller, L. J."State Interrogation in Nuclear Magnetic Resonance Quantum Information Processing," Phys. Rev. A 2004, 69(5-A),052302/1-052302/9.

Rodriguez, A.; Olsen, R.A.; Ghaderi, N.; Scheschekewitz, D.; Tham, F.S.; Mueller, L. J.; Bertrand, G. "Evidence for the Co-Existence of Two Bond-Stretch Isomers in Solution," Angewandte Chemie International Edition 2004, 43(37), 4880-4883.

Leskowitz, G. M.; Ghaderi, N.; Olsen, R. A.; Pederson, K.; Hatcher, M. E.; Mueller, L. J. "The Amide Rotational Barrier in Isonicotinamide: Dynamic NMR and Ab Initio Studies," J. Phys. Chem. A 2005, 109(6), 1152-1158.

Chen, L.; Olsen, R. A.; Elliott, D. W.; Boettcher, J. M.; Zhou, D. H.; Rienstra, C. M.; Mueller, L. J. "Constant-Time Through-Bond 13C Correlation Spectroscopy for Assigning Protein Resonances with Solid-State NMR Spectroscopy," J. Am. Chem. Soc. 2006, 128(31), 9992-9993.